Research and transparency

Bibliography and sources

The references connect the texts to relevant sources. The selection supports the detailed content and does not constitute a systematic literature review.

15 references
01

Gold and Mahrer

Gold JI, Mahrer NE. Is Virtual Reality Ready for Prime Time in the Medical Space? A Randomized Control Trial of Pediatric Virtual Reality… J Pediatr Psychol. 2018;43(3):266–275.

Source type: randomised study of VR during paediatric blood sampling. Evidence on the intervention modality; not a study of REALICA.

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02

Sanna and colleagues

Sanna G, Camporesi A, Diotto V, Abbiati G, Torri A, Gemma M. Virtual sedation as a substitute to pharmacological sedation during PICC placement in pediatric patients: A feasibility study. J Vasc Access. 2024;25(1):313–317. Published online in 2022.

Source type: feasibility study. Evidence on VR and paediatric vascular access.

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03

Fallea and colleagues

Fallea A, Treccarichi S, L’Episcopo S, et al. Virtual Reality Versus Monitor-Based Distraction in Children with Mild Intellectual Disability: A Preliminary Comparative Observational Study. Children (Basel). 2026;13(3):437.

Source type: prospective, comparative, non-randomised observational study using REALICA VR. Link to the full text:

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04

Stunden and colleagues

Stunden C, Stratton K, Zakani S, Jacob J. Comparing a Virtual Reality-Based Simulation App (VR-MRI) With a Standard Preparatory Manual and Child Life Program… J Med Internet Res. 2021;23(9):e22942.

Source type: randomised study of preparation for a simulated MRI. Not specific to OASI VR or to an autistic population.

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05

Davit and colleagues

Davit CJ, Hundley RJ, Bacic JD, Hanson EM. A pilot study to improve venipuncture compliance in children and adolescents with autism spectrum disorders. J Dev Behav Pediatr. 2011;32(7):521–525.

Source type: pilot study of preparation for blood sampling in autism, without VR. A methodological reference, not a validation of OASI VR.

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06

Tortora and colleagues

Tortora C, Di Crosta A, La Malva P, et al. Virtual reality and cognitive rehabilitation for older adults with mild cognitive impairment: A systematic review. Ageing Res Rev. 2024;93:102146.

Source type: systematic review. Concerns other VR interventions, not LUCIDA VR.

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07

Perra and colleagues

Perra A, Primavera D, Leonetti V, et al. Virtual reality cognitive remediation tool for individuals with mild cognitive impairment: study protocol for a feasibility randomized clinical trial. Front Public Health. 2024;12:1477279.

Source type: study protocol. Does not present efficacy results and does not concern LUCIDA VR.

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08

Wong and colleagues

Wong WWS, Wong GHY, Choy JCP, Li DSP, Lo YL. Utilization of Immersive Virtual Reality in Cognitive Stimulation Therapy (IVR-CST) for elderly with mild cognitive impairment… PLoS One. 2025;20(8):e0330686.

Source type: randomised pilot protocol. Does not present efficacy results and does not concern LUCIDA VR.

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09

Chirico and colleagues

Chirico A, Maiorano P, Indovina P, et al. Virtual reality and music therapy as distraction interventions to alleviate anxiety and improve mood states in breast cancer patients during chemotherapy. J Cell Physiol. 2020;235(6):5353–5362.

Source type: comparative study in patients with breast cancer during chemotherapy. Not a study of REALICA.

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10

Niki and colleagues

Niki K, Okamoto Y, Maeda I, et al. A Novel Palliative Care Approach Using Virtual Reality for Improving Various Symptoms of Terminal Cancer Patients… J Palliat Med. 2019;22(6):702–707.

Source type: prospective, multicentre, single-arm study without a control group. Not a study of REALICA.

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11

National Institute on Aging

National Institute on Aging. Memory Problems, Forgetfulness, and Aging. Section on Mild Cognitive Impairment.

Use in the document: general background on MCI and its distinction from dementia.

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12

NICE

National Institute for Health and Care Excellence. Dementia: assessment, management and support for people living with dementia and their carers. Guideline NG97. Recommendations 1.4.2, 1.4.4 and 1.4.5.

Use in the document: distinction between group cognitive stimulation, cognitive rehabilitation and cognitive training. Does not constitute approval or recommendation of LUCIDA VR.

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13

Mo and colleagues

Mo J, Vickerstaff V, Minton O, et al. How effective is virtual reality technology in palliative care? A systematic review and meta-analysis. Palliat Med. 2022;36(7):1047–1058.

Source type: systematic review with meta-analysis; quality of evidence rated very low. Not a study of REALICA.

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14

NICE on support for autistic children and young people

National Institute for Health and Care Excellence. Autism spectrum disorder in under 19s: support and management. Guideline CG170. Recommendations 1.1.6, 1.2.3, 1.3.1 and section 1.5 on everyday living skills.

Use in the document: reference for adaptive skills, communication and family involvement. It does not constitute a specific recommendation for OASI VR.

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15

Maskey and colleagues

Maskey M, Rodgers J, Grahame V, et al. A Randomised Controlled Feasibility Trial of Immersive Virtual Reality Treatment with Cognitive Behaviour Therapy for Specific Phobias… J Autism Dev Disord. 2019;49(5):1912–1927.

Source type: randomised feasibility trial of VR and cognitive behavioural therapy for specific phobias in autistic young people. An immersive projection environment; not a study of OASI VR or domestic skills.

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