Scientific Demonstrations and Studies – Rehabilitation with
REALICA VR
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The Science Behind VR Rehabilitation
Virtual reality as an ally for dentists and patients
Motor and cognitive rehabilitation supported by Virtual Reality (VR) is increasingly recognized as one of the most promising approaches in modern neurorehabilitation.
Clinical studies conducted with REALICA VR confirm that immersive training accelerates post-stroke recovery, improves motor coordination, stimulates neuroplasticity, and slows cognitive decline in neurodegenerative diseases.
Clinical Evidence
Collaborative research with hospitals and rehabilitation centers has demonstrated that REALICA VR:
- increases patient adherence thanks to engaging and gamified experiences,
- improves motor coordination, balance, and fine motor skills,
- stimulates memory, attention, and executive functions in patients with neurological disorders,
- enhances the effectiveness of traditional physiotherapy with personalized home-based programs,
- reduces fatigue and makes long-term rehabilitation more sustainable.
Scientific References on Cognitive Rehabilitation with Virtual Reality
- Benefits of Virtual Reality-Based Cognitive Rehabilitation Through Simulated Activities of Daily Living: A Randomized Controlled Trial with Stroke Patients
This study demonstrated that the use of a VR simulation (Reh@City), integrating cognitive tasks (attention, memory, visuospatial skills, executive functions), produced significant improvements in global cognition, attention, and memory compared to conventional rehabilitation. (BioMed Central) - Virtual Reality for the Rehabilitation of Acquired Cognitive Impairment: A Review (Catania et al., 2023)
A recent review exploring how VR is applied to cognitive rehabilitation in patients with neurological disorders, highlighting both the therapeutic potential and current limitations. (PMC) - The Role of Virtual Reality–Based Cognitive Training in Post-Stroke Patients: A Randomized Controlled Trial (Maggio et al., 2025)
In this RCT, the group that received VR-based cognitive training showed higher motivation, improved cognitive function (MoCA scores), and better emotional outcomes compared to the control group. (Nature) - Virtual Reality–Based Neurorehabilitation Support Tool for Cognitive Rehabilitation After Acquired Brain Injury (Prats-Bisbe et al., 2024)
A study evaluating an immersive VR tool for cognitive rehabilitation in patients with acquired brain injury, reporting promising results in cognitive engagement and recovery. (JMIR Neuro) - Can Virtual Reality Cognitive Rehabilitation Improve Executive Functioning and Coping Strategies in Traumatic Brain Injury? (De Luca et al., 2023)
A pilot study showing that non-immersive VR training can improve executive functioning, coping strategies, and mood in patients with traumatic brain injury. (MDPI – Brain Sciences) - The Utility and Application of Virtual Reality in Brain Injury Rehabilitation: Meta-Analysis (Min Zhang et al., 2025)
A meta-analysis revealing that VR-based interventions significantly improved cognitive functions (MoCA, FAB) and reduced depressive symptoms compared to control groups. (Dove Medical Press)
These studies show that VR-based rehabilitation can provide greater benefits than conventional methods, particularly when therapy is personalized, immersive, and motivating.
REALICA VR in Clinical Contexts
Based on current evidence, REALICA VR has been designed to:
- integrate gamification to improve patient adherence,
- provide ecological training scenarios that replicate daily activities,
- enable real-time monitoring for adaptive therapy,
complement traditional rehabilitation with home-based immersive programs.
Current Challenges and Future Directions
While results are highly promising, research also highlights some open challenges:
- Methodological variability across studies (protocols, duration, measures).
- Small sample sizes in many trials.
- Limited long-term follow-up data.
- Immersion and usability issues (avoiding motion sickness, ensuring comfort).
- Multimodal integration – combining VR with haptic feedback, biofeedback, and eye-tracking may further enhance outcomes.
A recent review on Extended Reality (XR) emphasizes the potential of multisensory input (visual, auditory, tactile) to increase ecological validity and therapeutic impact.
Collaborate with Us
Are you a researcher, clinician, or rehabilitation center interested in exploring the potential of VR?
Request our full clinical evidence portfolio.
Contact us to start a research collaboration or pilot project with REALICA VR.
